Integrative Physiology Isolated Rabbit Working Heart Function During Progressive Inhibition of Myocardial SERCA Activity
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چکیده
volume. Intermediate levels of SERCA function ( 50% of control) had only minor hemodynamic effects. Parallel experiments in field-stimulated isolated ventricular cardiomyocytes monitored intracellular Ca and cell shortening. On perfusion with thapsigargin, Ca transient amplitude and cell shortening fell to 70% of control followed by increased diastolic Ca concentration and diastolic cell shortening to achieve
منابع مشابه
Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity.
RATIONALE The extent to which sarcoplasmic reticulum Ca(2+)ATPase (SERCA) activity alone determines left ventricular (LV) pump function is unknown. OBJECTIVE To correlate SERCA activity with hemodynamic function of rabbit LV during thapsigargin perfusion. METHODS AND RESULTS Isolated rabbit hearts were perfused in working heart configuration, and LV pump function was assessed using a pressu...
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تاریخ انتشار 2012